Abstract

DEVELOPMENT AND EVALUATION OF TOPICAL ANTI-AGEING FORMULATION OF RESVERATROL

Pawan, Ankita Sharma* and Parveen Kumari

Abstract

Topical application gel formulations are designed to be spread on to the skin or specific membranes of mucous for lubricating or restorative properties, or for the local or transdermal entry of medication. By integrating the medication inside the matrix of hydrogel, topical distribution of medications can be accomplished, preventing first-pass metabolism and promoting localized response in the treatment of soreness and skin related conditions. The purpose of this work was to characterise and assess the anti-aging properties of hydrogel formulations loaded with resveratrol. An effort was made to create topical hydrogel formulations of resveratrol using hydrophilic polymers such as Carbopol 934 at different doses. Physical appearance, viscosity, pH, drug content, spreadability, in-vitro release of drug, and analysis of anti-ageing property utilising the DPPH scavenging assay technique were all used in this study to characterise hydrogel resveratrol. According to the results of the organoleptic test, every formula was homogenous in consistent behaviour soft, and white in colour. Tests for spreadability, pH, and viscosity revealed that every formula was within the typical range for topical treatments. Tests of anti-aging activity have also shown that raising the dose increases the formula's IC50 value and percentage of inhibition. Following exposure to increased temperatures (40 ± 2oC) and humidity levels (75 ± 5%RH), no significant alterations in the formulation's physicochemical characteristics were noted. Based on in vitro testing, the gel formulation (F4) was determined to be appropriate for topical use. These findings imply that resveratrol topical gel formation as an anti-aging hydrogel is feasible.

Keywords: Resveratrol. Hydrogel. Anti-ageing, DPPH, Topical Delivery.