Abstract

DESIGN, SYNTHESIS AND IN-VITRO STUDIES ON NOVEL CINNOLINE DERIVATIVES AS POTENTIAL ANTI-INFLAMMATORY AGENTS

Dr. P. R. Logeshkumar*, Dr. S. K. Senthilkumar, A. Jayavarthani, R. Jeevitha, S. Kanimozhi, J. Karthick and K. Karthiga

Abstract

Cinnoline is a heterocyclic aromatic organic compound which is also known as 1,2 - diazanaphthalene or benzo-1,2-diazine. It's a bicyclic structure, featuring a benzene ring fused with a diazine ring (a six-membered ring with two nitrogen atoms). It is isomeric with other nitrogen-containing heterocycles like quinoline and phthalazine. Cinnoline derivatives exhibit wide-range of pharmacological activities including anti-microbial, anti-fungal, anti-malarial and anti-inflammatory properties. Pale yellow crystalline solid, Aromatic and planar in nature. The starting compound of cinnoline is Aniline and Sodium nitrite. Some of the cinnoline derivatives are 4 -phenyl cinnoline, Ethyl cinnoline, Methyl cinnoline and Cinoxacin.

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