Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF NAPROXEN SODIUM

Patil Jayesh Vilas, Ms. Shabnam Beg, Dr. Revathi A. Gupta and Dr. Gaurav Jain*

.

Abstract

The current study aims to formulate and evaluate mouth dissolving tablets (MDTs) of Naproxen Sodium to enhance patient compliance and provide rapid onset of action. The MDTs were prepared using direct compression and sublimation methods employing various superdisintegrants including Crospovidone, Sodium Starch Glycolate, and Croscarmellose Sodium, with urea as the sublimating agent. Preformulation studies confirmed the identity and purity of Naproxen Sodium. Nine different formulations (F1–F9) were developed and evaluated for micromeritic properties, drug content, disintegration time, wetting time, water absorption ratio, friability, and in vitro drug release. Among the formulations, F9 containing 4% Crospovidone showed the best performance with disintegration time of 16 seconds and 97.34% drug release within 60 minutes. Stability studies confirmed the formulation’s stability under accelerated conditions. The results demonstrated that the formulated MDTs of Naproxen Sodium could be a promising alternative to conventional tablets for immediate pain relief.

Keywords: Naproxen Sodium, Mouth Dissolving Tablets, Superdisintegrants, Crospovidone, Sublimation, In-vitro Drug Release.