Abstract

FORMULATION AND INVITRO EVALUATION OF TRANDOLAPRIL SOLID LIPID COMPACT NANOPARTICLE

S. Selvaraj*, K. Nadima Rasheed and P. Perumal

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Abstract

In this study, Trandolapril was formulated into tablets using Solid Lipid Nanoparticles (SLNs) with varying concentrations of Compritol 888 ATO (5%, 10%, and 15%). SLNs were prepared by melting the lipid, dissolving Trandolapril in ethanol, and adding surfactant (Polysorbate 80) and co-surfactant (PEG 400), followed by high-speed homogenization. The SLNs were then converted into tablets with excipients like microcrystalline cellulose, Neusilin®, and Aerosil. Characterization using FTIR and DSC confirmed no interaction between the drug and excipients. Entrapment efficiency was found to be 81.36%. Flow properties of granules were also evaluated. Dissolution studies using USP Type I apparatus in pH 6.8 buffer showed improved drug release for SLN-based tablets compared to a marketed sample (Aurobindo Pharma, USA), especially at lower Compritol concentrations.

Keywords: Trandolapril, Solid Lipid Nanoparticles.