Abstract

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF CHALCONE-BEARING BENZIMIDAZOLE DERIVATIVES AS ANTIINFLAMMATORY AGENTS

Kumari Anjali*, Jain Shuchi, Jain Sachin and Venkgurlekar Sudha

.

Abstract

Inflammation is a fundamental biological response of living tissues to harmful stimuli, including physical injury, infection, toxins, and immune reactions. It is an essential component of the innate immune system, acting as the body’s first line of defense against infections and injuries. The main goal of this study was to come up with, make, and test biologically chalcone-containing benzimidazole derivatives that could be used as anti-inflammatory drugs. The study successfully showed a methodical way to create new molecules by combining two pharmacologically important scaffolds: chalcone, an α,β-unsaturated carbonyl system known for its anti-inflammatory properties, and benzimidazole, a privileged heterocyclic structure known for its wide range of biological activities. A new group of chalcone-containing benzimidazole derivatives was made using the well-known Claisen–Schmidt condensation process, which is often used to make α,β-unsaturated carbonyl systems. The chalcone moiety is made when a ketone and an aldehyde come together in this process, which takes place in basic conditions. This trend strongly supports further development of EWG-substituted derivatives as promising anti-inflammatory agents.

Keywords: chalcone-containing benzimidazole, scaffolds, Claisen–Schmidt condensation, α,β-unsaturated carbonyl systems.