Abstract

A REVIEW ARTICLE ON MATRIX RELEASE TABLETS

Hina Tousif S.*, Farida Banu S., Karishma S., Shaziya Tanzeem T., Shaguftha T., Jagan V. and Banny S.V.

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Abstract

The progress of the market might induce the development of new formulations and controlled release systems. In the past decades huge efforts were focused on making controlled release systems. These platforms are able to regulate drug dissolution from the formulation in a controlled manner. Regulating and extending drug release is advantageous from many aspects. Reduced fluctuations of the blood concentration of the active ingredient might result decreased occurrence and severity of adverse effects.[1] Prolonging of the plasma concentration of drugs with short half-life also means reduced administration frequency[2],[3] and improved patient compliance.[53] Benefits mentioned above are particularly important not only for patients themselves[4],[5] but for clinicians and pharmaceutical technologists also.[2] The word matrix originates from the Latin, where the original meaning was dam or womb.[7] Later in different scientific fields it had other meaning with one common, something which embeds various and distinct structures or materials.[8] In pharmacy, the matrix is the carrier or vehicle in which the active pharmaceutical ingredient (API) is homogenously distributed or dispersed. The earliest publication with the title containing tablet matrix is from 1958.[9] The rate of dissolution is controlled by either of following mechanisms: * Altering the rate of fluid penetration into tablet by altering the porosity of tablet. * Decreasing the wettability of tablet. * Slow dissolution rate of polymer[10,11] (Figure 5).

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