Abstract

FORMULATION AND CHARACTERIZATION OF TENOFOVIR DISOPROXIL FUMARATE POLYMERIC NANOPARTICLE

*Umesh Kumar Chaurasia, Deepak Kushwaha, Shubham Chaurasiya

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Abstract

There is a need to design alternative delivery systems to overcome the drawbacks of the current HIV/AIDS treatment therapy and improve patient compliance. The treatment of HIV/AIDS requires sustained release of the drug to reduce the frequency of the drugs as well as targeting to the tissues which act as latent HIV reservoirs, both of which can be successfully achieved by the use of nanosystems for delivery of anti-retroviral drugs. Nanosystems are versatile drug delivery systems, with an ability to overcome physiologic barriers and to guide the drug to specific cells or intracellular compartments due to their small size, typically in the 10 1000 nm range. Nanosystems offer several advantages, such as the protection of drugs against degradation, targeting of drugs to specific sites, and tailoring the release kinetics to provide prolonged release of the drugs. Polymeric nanoparticles, solid lipid nanoparticles, liposomes, nanosuspensions and nanoemulsions have been reported to enhance the effective delivery of the drugs. Our research group has previously worked on development of particulate systems for Nelfinavir mesylate (NFV), a protease inhibitor.

Keywords: Entrapment, nanoparticles, Anti-retroviral therapy, Formulation, polymer.