Abstract

FORMULATION AND EVALUATION OF SPRAY BANDAGE FOR WOUND HEALING

*Mr. Shivanand K., Vidhya Bharti, Umair Hamzda, Datta Mane

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Abstract

To formulate a spray bandage that provides good protective and therapeutic activities for an extended duration, and forms a film that acts as a protective barrier for open wounds or other topical diseases, it is easy to use and apply by spraying directly on the affected area. Thes pray forms a film within a few seconds and has good patient compliance. Curcumin is useful in various activities such as antitumor, antioxidant, anti-arthritic, anti-amyloid, anti-inflammatory, bacterial infections, wound healing, and tissue repair. Curcumin has low gastrointestinal (GI) stability; hence, it is administered through a topical drug delivery system for sustained release of the drug. Film forming sprays offer many advantages compared to conventional topical preparations because they provide uniform drug distribution and dosage, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Conventional formulations for topical and dermatological administration of drugs have certain limitations, such as poor adherence to the skin, poor permeability, and compromised patient compliance. For the treatment of diseases of body tissues and wounds, the drug must be maintained at the site of treatment for an effective period. Topical filmforming systems are emerging drug delivery systems designed for topical application to the skin. These systems adhere to the body, forming a thin transparent film, and provide delivery of the active ingredients to the tissue. They are intended for skin application as emollients or protectives and for local action or transdermal penetration of medicaments for systemic action. Further, various types of film forming systems (sprays/solutions, gels, and emulsions), along with their evaluation parameters, have also been reviewed.

Keywords: Spray bandage, Anti-inflammatory, Topical film, Transdermal, Film forming.