Abstract

REVIEW ON MICROSPHERES

Moulika P.*, Nithisha Ch., Nagini T., Sravani V., Sahithyareddy, Bhargavi V.

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Abstract

Microspheres are tiny, round particles with diameters typically between 1 to 1000 micrometers, extensively studied and utilised for their unique characteristics in various fields, including pharmaceuticals and biotechnology. This review explores the key Characteristics, Microsphere types, Preparation methods, Recent advancements, and diverse Applications of microspheres. Microspheres come in various types, including bioadhesive microspheres, Magnetic microspheres, floating microspheres, and Polymer microspheres. The preparation of microspheres involves several techniques, including spray drying, Solvent Evaporation, Microencapsulation by Hot Melt Method, single emulsion method, Double emulsion method, Spray congealing and drying. Recent Advancements in microspheres like Important applications for the polymer chitosan, effects of reducing cholesterol, Orthopaedic Patients, Chitosan as Permeation Enhancer, Transforming growth factor (TGF-β) promotes the formation of bones. In terms of applications, microspheres have been predominantly employed in regulated medication administration, where they enhance the bioavailability and reduce side effects. Using Microspheres to Deliver Vaccines, Tissue Engineering, Biomedical Imaging, and Chemoembolization. Challenges such as Scalability, stability, biocompatibility, and large-scale production are also discussed.

Keywords: Microspheres, Microencapsulation, Controlled drug delivery, Novel drug delivery, Applications.