Abstract

MICRO-SIZED LIPID CARRIERS: SMEDDS FOR EFFICIENT ORAL DRUG DELIVERY

Devender, Dr. Parveen Kumari, Astha Singh*

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Abstract

Nowadays, the majority of new drug moieties coming through combinatorial chemistry or high-throughput screening have poor solubility problems in physiological fluids, which ultimately leads to low bioavailability. These drugs are categorised as biopharmaceutics classification system class 2, as they have low solubility with good permeability properties. Among various techniques currently used to rectify this solubility problem, SMEDDS (self-micro emulsifying drug delivery system) is thought to be a superior and more sophisticated method. Due to improved oral bioavailability, dose reduction, a physical relationship between drug absorption, selection of drug target for specific absorption window in the GIT, and avoidance of drugs from undesirable workers. SMEDDS, a sensitive gut environment, is getting more attention. SMEDDS can be packaged in soft gelatin, which is physically stable and easy to manufacture. After consumption, they form a microemulsion that carries the drug with a large surface area. Emulsions will increase drug absorption due to intestinal lymphatics and disperse the drug in the aqueous phase of the intestinal fluid. This current article provides a comprehensive review on SMEDDS as a potential solution for poorly soluble compounds and provides a brief overview of the compound, evaluation/characterization, market report, published/issued patents, etc.

Keywords: SEDDS, SMEDDS, Micro-emulsion, BCS, Ternary diagram.