Abstract

A REVIEW ARTICLE ON ‘’FORMULATION OF COLON-TARGETED TABLETS FOR ANTI-INFLAMMATORY DRUGS’’

*Nitesh Kumar, Mr. Gopal Kumar, Mr. Rajaram R. Rajbhar, Mr. Sachin Kumar

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Abstract

Colon-targeted tablets for anti-inflammatory drugs are designed to deliver medication directly to the colon, where it is most needed, especially for conditions like Crohn’s disease and ulcerative colitis. These tablets are made to pass through the stomach and small intestine intact, using special coatings or controlled-release systems that only activate once they reach the colon. Materials like Eudragit S are commonly used because they remain stable in the acidic stomach but dissolve in the higher pH environment of the colon. Some tablets also use biodegradable materials that break down slowly in the colon, releasing the drug gradually. However, developing these tablets is challenging due to individual variations in digestive pH and transit time, which can affect drug release and effectiveness. Despite these challenges, colon-targeted tablets improve treatment by increasing drug efficiency, minimizing side effects, and encouraging patient adherence. Still, further advancements are needed to make these therapies more consistent and reliable for all patients.

Keywords: Drug delivery systems and the large intestine, Targeting the colon, Gastrointestinal microbiota and microbiome, Oral biologics and biopharmaceuticals, Inflammatory bowel disease and drug products, Artificial intelligence and machine learning.