Abstract

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM GEL - USING CARBOPOL 934 AND 940

S. Nandhini*, M. Sakthivel, S. Mohammed Halith, S. Arun Kumar, A. Basheer Mohamed, S. Ithayathulla, K. Karthick

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Abstract

Gels are getting popularity nowadays when compared with other semisolid dosage form like ointments, creams, lotion and pastes due to their stability and controlled release. Gels formulations are substitute for oral route of administration and to avoid first pass metabolism. The present research has been undertaken with the aim to develop the formulation of Aceclofenac sodium Gel using different grades of gelling agents such as Carbopol 934p and Carbopol 940 in different concentration. Aceclofenac Sodium is recommended in long term use of rheumatoid arthritis and osteoarthritis. Gels are evaluated by following parameter such as pH, homogeneity, grittiness, drug content, viscosity, spreadability, extrudability, skin irritation studies. FTIR studies showed that no interaction between drug, polymer and excipients. The study concluded that the Carbopol 934p was suitable for gel preparation when compared to Carbopol 940.

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