Abstract

DEVELOPMENT AND CHARACTERIZATION OF VONOPRAZAN FUMARATE LOADED FLOATING MICROSPONGES

Deepshikha Tiwari*, Dr. Kamlesh Dashora, Dr. Praveen Khirwadkar

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Abstract

Peptic ulcer disease (PUD) is defined by discontinuity in the inner lining of the gastrointestinal (GI) tract caused by gastric acid production or pepsin. It penetrates the muscularis propria layer of the stomach epithelium. It mainly affects the stomach and proximal duodenum. It could affect the lower oesophagus, distal duodenum, or jejunum. Antisecretory drugs used for the treatment of peptic ulcer disease (PUD) include H2-receptor antagonists and proton pump inhibitors (PPIs). Potassium-competitive acid blockers (PCABs), such as vonoprazan, are a new class of acid suppressants that hold great potential for improving the treatment of peptic ulcer diseases. Microsponges are polymeric delivery mechanisms made up of porous microspheres. They are little, sponge-like spherical particles with a large porous surface. Furthermore, they may improve stability, reduce side effects, and optimize drugs release. Microsponges are porous polymeric microspheres that are mostly used for topical applications but have lately been employed for oral delivery. In this research paper we developed and characterised vonoprazan fumarate loaded microsponges. Microsponges drug delivery system can provide extended release of the drug. Ten formulations of floating microsponges were prepared using Eudragit L100 as extended release polymer and ethyl cellulose as a polymer which facilitated buoyancy to the microsponges. Characterization of the microsponge was done on various parameters such as production yield, encapsulation efficiency, particle size analysis, SEM analysis, in vitro dissolution studies with drug release kinetics as well as in vitro buoyancy studies.

Keywords: Microsponges, Vonoprazan fumarate, Peptic Ulcer, Extended Release, Bouyancy.