Abstract

A REVIEW ON MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM

*Shwetha G L., Subhan Sab

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Abstract

Extensive efforts have been focused on targeting Drug delivery system in a particular region of the body for extended period of time not only for local targeting of drug but also for better compliance of systemic drug delivery. Among the various routes of administration, oral route is the most suitable, convenient and widely accepted. Drug actions can be improved by developing new oral drug delivery systems such as the mucoadhesive buccal drug delivery system. Mucoadhesive drug delivery system prolongs the residence time of the dosage form at the site of application or absorption and facilitate an intimate contact of the dosage form with the underline absorption surface and thus contribute to improved and better therapeutic performance of the drug. Buccal dosage forms can be of Matrix or Reservoir types and they involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity. This review highlights a brief description of advantages, limitations of buccal drug delivery and theories of bioadhesion, mucoadhesive polymer, mechanism of buccal absorption along with mucoadhesive dosage form, factors affecting mucoadhesion.

Keywords: Anatomy, Mucoadhesion, Bio-adhesion, Mucoadhesive systems, Mucoadhesive polymers and Drug delivery.