Abstract

BIO-INSPIRED AND BIOMIMETIC DRUG DELIVERY SYSTEMS: A NOVEL APPROACH TO CANCER THERAPY

N. Tahaseen*, S. Anand, N. Anandhan, R. Thenmozhi, K. Vaishnavi, Dr. G. Mariyappan and V. Arunachalam

.

Abstract

Cancer continues to be a primary cause of death globally as existing treatments are frequently controlled by non-targeted drug delivery, systemic side effects, quick elimination and resistance to multiple drugs. To reduce these issues, bio-inspired and biomimetic drug delivery systems have arisen as novel strategies to improve therapeutic accuracy and effectiveness. Bio-inspired systems are originating from natural sources including bacteria, viruses, mammalian cells and exosomes to utilize intrinsic biological functions such as immune evasion, tumor targeting and extended circulation. Biomimetic systems are designed to follow these functions, react to stimuli in the tumor microenvironment such as pH, hypoxia, enzymes, and redox potential to facilitate controlled and localized drug release. Hybrid nanocarriers combining synthetic and biological components enhance targeting, stability and biocompatibility even more. Although these advanced platforms show considerable potential in preclinical and initial clinical studies, additional research is required to reduce scalability, standardization, and regulatory issues. In general, bio-inspired and biomimetic drug delivery systems signify a significant change in personalized cancer treatment, providing safer and more efficient therapeutic options.

Keywords: Bio-inspired medication transport, Biomimetic nanoscale carriers, Precision medication delivery, Bacteria-assisted therapy, Hybrid medication delivery systems, Regulated drug release.