Abstract

FORMULATION AND EVALUATION OF ALOE NIEBUHRIANA EXTRACT AS NATURACEUTICAL EFFERVESCENT GRANULES NOVEL DRUG DELIVERY SYSTEMS FOR ANTIDIABETIC ACTIVITY

Prof. Dr. Mahmoud Mahyoob Alburyhi*, Prof. Dr. Bushra Abdulkarim Moharram

Abstract

Ethnomedicine exhibits potential in developing affordable effective antidiabetic agents. The present study is based on the formulation of effervescent granules NDDS of Aloe niebuhriana latex extract. Six formulations were prepared using different acids, salts, diluents and superdisintegrants by the wet granulation method. The prepared granules were evaluated for flow property (like angle of repose, bulk density, tapped density, Hausner’s ratio) pH, Effervescence time, and organoleptic properties studies. Effervescent granules have occupied a unique place in the field of pharmaceutics. Widely use in clinical diagnosis of heart burn, urinary tract infection, acidity. They contain one or more active pharmaceutical ingredient with or without excipients. Due to its onset of action will be get fast, so effervescent granules are mostly used. Effervescent granules are uncoated granules containing drug, acid substances, carbonates or hydrogen carbonate which rapidly react with water and liberate co2. Six formulations containing the extract were prepared (F1–F6), and F6 containing 200 mg of the extract was selected for optimization due to its favorable odor, taste, foaming, and effervescent properties, high solubility, and absence of turbidity and adhesion. The formulated F6 granules successfully met the quality parameters assessed including flow time, pH effervescent time, angle of repose, bulk density, tapped density, Carr’s index, and Hausner’s ratio. It was concluded that among the all formulations of A. niebuhriana extract effervescent granules NDDS the F6 was found to be as an optimized effervescent granules NDDS according to the formulation F6 exhibited effervescence time within 60 sec and successfully met the quality parameters, so the F6 was the best formulation of A. niebuhriana extract effervescent granules NDDS as an advanced phytotherapy approach for antidiabetic activity.

Keywords: Aloe niebuhriana, Diabetes, Antidiabetic activity, Effervescent Granules NDDS, Herbal Formulation, Novel drug delivery systems.