Abstract

THE THERAPEUTIC ROLE OF WITHANIA SOMNIFERA IN CANCER MANAGEMENT: A META-ANALYTICAL PERSPECTIVE

Prabha Chauhan, Surbhi Srivastava, Akanksha, Apurva Ahlawat, Shivani Belwal, Vinod Kumar Gupta*

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Abstract

Withania somnifera (WS), also known as Ashwagandha, is an herb that has been utilized in traditional Indian medicine since the time of Ayurveda. According to studies on WS and its chemical components which include Withaferin A, Withanolide D and others, is useful in both the prevention and treatment of various cancers, including those of the colon, blood, lung, skin, breast, renal, fibrosarcoma, prostate, pancreatic, and other types by inhibiting the growth and spread of cancer cells, regulating cell cycle markers, and modifying haematological, biochemical, and physiological variables, malignant melanoma, and biochemical variables, cell cycle marker regulation, etc. Since low immunity and the body's original normal cells are both destroyed during radiotherapy and chemotherapy thus patients can use this medicinal herb WS as an alternative treatment for cancer or in conjunction with chemotherapy or radiation therapy as an adjunctive or complementary treatment. WS aids in preventing these negative effects and promotes better healing and lifestyles for patients.

Keywords: Withania somnifera, Ayurveda, Cancer, Withaferin A, Withanolide D.