Abstract

IN VITRO ANTIVIRAL POTENTIAL OF CERTAIN INDIAN MEDICINAL PLANTS AGAINST POLIO VIRUS

Dr. Seema Jain*, Dr. Rakesh Bhargava, Mr. Sanjeev K. Jain

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Abstract

Four Indian medicinal plants viz tulsi (Ocimum sanctum Linn), neem (Azaderichta indica Juss), lehson (Allium sativum Linn) and adrak (Zingiber officinale A. Ross) were assessed for their in vitro potential to inhibit poliovirus type 3 replication using VERO cells. Results showed that a non-toxic range of 22.5 to 175 mg/ml) uconcentration of ethanolic extract of tulsi leaves inhibited poliovirus type 3 replication as compared to 225 to 1.75 mg per ml pf aqueous extract. Percentage inhibition of virus determined by virus inhibition assay for ethanolic and aqueous extracts of tulsi leaves was found 99.90% and 99.65% respectively. Aqueous extracts as well as ethanolic extracts of neem, lahson and adrak did not show significant viral inhibition.

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