Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE BUCCAL DELIVERY OF TERBUTALINE SULFATE

Tirumala Devi Kolli*, Anand Vardhan Dommeti, Prasada Rao Manchineni

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Abstract

Buccal tablets of terbutaline sulphate were developed using bioadhesive polymers along with other excipients to produce modern formulations. In this study, the effects of bioadhesive polymers such as HPMC K4M, HPMC K15M, HPMC K100M were evaluated. The tablets were prepared by direct compression and characterized for thickness, hardness, weight variation, friability, drug content, in-vitro drug release. In-vitro drug release studies were conducted using 900 ml of Phosphate buffer at 50 rpm in a USP type II dissolution apparatus for 12 hours. The results indicated that drug release increased with higher concentrations of cellulose derivatives (HPMCK100M), while it decreased with increasing amounts of MCC. Various kinetic models were applied to analyze the release kinetics of the dosage form. Overall, the physical properties of the formulated buccal tablets were within acceptable limits. Whereas from the dissolution studies it was evident that the formulation (F7) showed better and desired drug release pattern i.e., 98.76 % in 12 hours. It followed zero order release kinetics mechanism.

Keywords: Controlled Release, Buccal delivery, Terbutaline sulfate, swelling index, Bioadhesive polymers.