Abstract

FORMULATION AND EVALUATION OF PANTOPRAZOLE LIPOSOMES BY THIN FILM HYDRATION FOR GERD MANAGEMENT

*Sneha N. R., Krishna K. R., Parthiban S.

Abstract

The present study aimed to develop and evaluate a liposomal drug delivery system of Pantoprazole sodium for effective management of Gastroesophageal Reflux Disease (GERD). Liposomes were prepared using the thin film hydration method with soy lecithin and cholesterol as lipid components, serving as vesicle-forming and stabilizing agents. The formulations were characterized for particle size, zeta potential, surface morphology, entrapment efficiency, and in-vitro drug release. FTIR analysis confirmed the absence of any chemical interaction between Pantoprazole sodium and excipients, indicating compatibility. SEM imaging revealed spherical, uniform, and smooth vesicles, confirming successful liposome formation. The formulation exhibited particles with uniform distribution, good physical stability, and high drug entrapment, suggesting efficient incorporation of the drug within the lipid bilayer. In-vitro release studies demonstrated a biphasic pattern, consisting of an initial burst release followed by sustained drug release over an extended period. The results also indicated that lipid composition significantly influenced vesicle characteristics and drug release profile. Overall, liposomal Pantoprazole sodium provides a stable, controlled, and sustained drug delivery system, with potential to enhance therapeutic efficacy and improve patient compliance in GERD management.

Keywords: Gastroesophageal Reflux Disease, Proton pump inhibitors, Liposomes, Drug Delivery system, thin film hydration.