Abstract

CHARACTERIZATION OF MICONAZOLE NITRATE LOADED TOPICAL MICROEMULSION GEL USING CARICA PAPAYA SEED OIL AND CINNAMON OIL

Mohammad Ali, Kavana S. Gowda*, Parthiban S.

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Abstract

The present study aimed to develop and evaluate Miconazole nitrate microemulsions incorporating Carica papaya seed oil and Cinnamon oil to enhance antifungal activity. Microemulsions were prepared by titrating various ratios of oil to Smix with water, and the microemulsion region was identified using pseudo-ternary phase diagrams. The formulations were characterized for compatibility, transmittance, viscosity, pH, drug content, globule size, zeta potential, and stability. FTIR studies confirmed no significant interaction between the drug and excipients. Among all, CPM3 and CCM3 were selected as optimized formulations due to their high transmittance, low viscosity, high drug content, and ideal pH suitable for topical application. These optimized microemulsions were incorporated into 1% Carbopol 934 gel to form CPM3-G1 and CCM3-G2 gels. The prepared gels exhibited good spreadability, appropriate viscosity, and sustained drug release profiles. In vitro studies confirmed prolonged drug release. The study concluded that the combination of Miconazole nitrate with Carica papaya seed oil and Cinnamon oil in microemulsion form significantly improves topical drug delivery and provides better therapeutic efficacy.

Keywords: Microemulsion, Pseudoternary phase diagram, Miconazole nitrate, Carica papaya seed, Cinnamon oil, Anti-fungal agent.