Abstract

NANOTECHNOLOGY-ENABLED TRANSDERMAL DELIVERY OF KETOPROFEN FOR RHEUMATOID ARTHRITIS

Lavanya G., Darshini H. B., *Rama Bukka, Nidhi Malaviya, Sachindra L. Nargund

Abstract

The present study aimed to develop and evaluate nanoparticles loaded transdermal drug delivery system of Ketoprofen for Rheumatoid arthritis. Solid lipid nanoparticles of Ketoprofen were prepared by Highspeed homogenization technique, by using Face centred CCD with 23 factorial design with 6 axial points and 1 center point that gives 15 trials with low, Intermediate and high limits of GMS was used as lipid and Tween 80 and Span 60 were used as surfactants. Particle size and Entrapment Efficiency were evaluated statistically. Numerical optimization recommended the optimized formulation with Particle size of 129nm, entrapment efficiency (83%) and drug release (106.4%). The optimised formulation was subjected for TEM and the surface of the particles were smooth and there is no aggregation of particles. So, optimized formulation of nanoparticles was then used for formulation of transdermal patch using HPMC K100 M as polymer and PEG-400 as plasticizer. The patch was evaluated for Weight uniformity, Folding endurance, Thickness, Drug Content, In- vitro drug release and Ex-vivo studies. The release of drug from the SLNs formulation was found to be more than the release from the transdermal patch.

Keywords: Nanoparticles: Ketoprofen, GMS, Tween80, Span 60, Transdermal Patch: HPMC K100 M, PEG- 400.