Abstract

FORMULATION AND DEVELOPMENT OF CEFDINIR SUSTAINED RELEASE TABLETS USING VARIOUS RETARDING POLYMERS

Marisetti Vyshnavi*, Raparti Srujana, B. Shailaja

Abstract

Sustained release tablets of Cefdinir were formulated by using Tamarind Gum, Carnauba Wax, and Fenugreek. The tablets were evaluated for Preformulation studies like angle of repose, blukdensity, compressibility index and physical characteristics like hardness, weight variation, friability and drug content. In-vitro release of drug was performed in phosphate buffer pH 6.8 for twelve hours. All the physical characters of the fabricated tablet were within acceptable limits. The tablet with Carnauba Wax (F6) shows a better sustained drug release (99.72%) was obtained with the matrix tablet. It is cleared through the dissolution profile of cefidinir from matrix tablets prepared using different polymers were indicated an increase in the polymer ratio retarded the drug release to a greater extent.

Keywords: Cefidinir, Tamarind Gum, Carnauba Wax, and Fenugreek Sustained release matrix tablets.