Abstract

FORMULATION AND EVALUATION OF NANOEMULSION OF TRIDAX PROCUMBENS EXTRACT FOR THE TREATMENT OF VITILIGO

Abhay Mishra, Govind Kumar*, Junaid, Pranshu

Abstract

Vitiligo is a chronic depigmenting disorder caused by the loss of melanocytes, resulting in white patches on the skin. Oxidative stress, autoimmunity, and genetic factors play significant roles in its pathogenesis. Conventional treatments have limitations such as slow response, side effects, and recurrence. Herbal alternatives, particularly Tridax procumbens, have shown promising antioxidant and melanocyte-stimulating properties. The present study aims to formulate and evaluate a nanoemulsion of Tridax procumbens ethanolic extract for potential topical therapy in vitiligo. Nanoemulsions were prepared using Capryol 90 (oil phase), Tween 80 (surfactant), PEG 400 (co-surfactant), and distilled water (aqueous phase) through the high-energy emulsification method. The formulations were evaluated for droplet size, zeta potential, viscosity, pH, and in vitro stability. Results demonstrated stable nanoemulsions with droplet size ranging from 80–120 nm and suitable physicochemical properties for topical application. This study provides a basis for further in vivo and clinical evaluation of herbal nanoemulsion for vitiligo treatment.

Keywords: Vitiligo, Tridax procumbens, Nanoemulsion, Topical therapy, Herbal formulation.