Abstract

FORMULATION AND IN VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF GABAPENTIN

K. Durga Mounika*, R. Srujana, G. Manisha

Abstract

In the present study, an attempt has been made to develop controlled release tablets of Galantine by selecting different types of polymers Eudragit S 100, Ethyl Cellulose and Hydroponically Cellulose as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F8 formulation showed maximum % drug release i.e., 98.94 % in 12 hours. Hence it is considered as optimized formulation F8 which contains Hydroponically Cellulose (100 mg). Whereas the formulations with Eudragit S 100 showed more retarding with low concentration of polymer. The formulations with Ethyl Cellulose were unable to produce the desired drug release pattern. The results of the accelerated stability study of final formulation for 3 month revealed that storage conditions were not found to have made any significant changes infinal formulation.

Keywords: Gabapentin, Eudragit S 100, Ethyl Cellulose, Hydroponically Cellulose and Controlled Release Tablets.