Abstract

STUDY ON WOUND HEALING ACTIVITY BY USING PLANT LANTANA CAMARA AND TRIDAX PROCUMBENS

Ganesh Vivek Kalyankar*, Vishnukanth Sambhaji Kadam, Karan Vitthal Kalaskar, Renuka Yogaji Kale, Bhuvan Ashok Kamble, Meena Pandurang Pisal

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Abstract

Wound healing is a complex biological process involving inflammation, tissue formation, and remodelling. Traditional medicine has long utilized various medicial plants for enhancing wound healing. In this study, the wound healing potential of two ethnomedicinal plants, Lantana camara and Tridax procumbens, was investigated through in vivo models. Extracts from the leaves of both plants were prepared using solvents such as ethanol and aqueous solutions. The phytochemical analysis revealed the presence of flavonoids, tannins, saponins, and terpenoids compounds known to promote tissue regeneration and possess antimicrobial properties. Wistar rats were subjected to excision and incision wound models, and the rate of wound contraction, epithelialization period, and tensile strength were evaluated over a 14-day period. The results showed a significant improvement in wound contraction and healing rate in groups treated with the combined extracts, compared to the control and standard treatment groups. The synergistic effect of L. camara and T. procumbens is attributed to their anti-inflammatory, antioxidant, and antimicrobial properties. This study supports the traditional use of these plants and suggests their potential as natural, cost-effective alternatives in wound management.

Keywords: Wound healing, Lantana camara, Tridax procumbens, herbal therapy, antiinflammatory activity, collagen synthesis.