Abstract

FORMULATION AND EVALUATION OF POLYMER MODIFIED PUNARNAVA HERBAL TABLETS FOR KIDNEY STONE AND ANTIAGING EFFECT

Prof. Amar S. Kulkarni*, Dr. Amol T. Ubale, Aliya A. Patel, Shreyas R. Patil, Chaitanya S. Pawar, Sakshi R. Prabhu, Pratham D. Vetkar

.

Abstract

Kidney stone disease (nephrolithiasis) remains a major global health problem, affecting millions and characterized by high recurrence rates and limited efficacy of conventional therapies. The increasing shift toward natural and safe alternatives has renewed interest in Ayurvedic herbs with proven nephroprotective and anti-aging potential. This review focuses on the formulation and evaluation of polymer-modified herbal tablets incorporating Punarnava (Boerhavia diffusa), Tulsi (Ocimum sanctum), and Ashwagandha (Withania somnifera). Each herb offers unique therapeutic properties: Punarnava acts as a potent diuretic and anti-inflammatory agent promoting renal detoxification; Tulsi provides antioxidant and antiurolithic effects; while Ashwagandha exhibits adaptogenic and anti-stress benefits contributing to cellular rejuvenation. The use of modified rice starch as a natural polymer matrix ensures sustained release and improved bioavailability of active phytoconstituents, while excipients like gum acacia and ispaghula husk enhance tablet stability and disintegration. This integration of traditional herbal knowledge with modern pharmaceutical technology presents a standardized, patientcompliant formulation for effective kidney stone management and age-related oxidative stress reduction. The review concludes that polymer-modified herbal tablets represent a promising, safe, and economical alternative for nephrolithiasis prevention and therapy, warranting further pharmacological and clinical validation.

Keywords: .