Abstract

PREPARATION AND EVALUATION OF SOLID DISPERSIONS OF TELMISARTAN FOR ENHANCED SOLUBILITY: A COMPREHENSIVE REVIEW

Nibedita Pradhan*, Nancy Mohapatra, Pruthwiraj Dash, Pratik Panda, Monoranjan Sahu, Sonali Behera, Pratik Kumar Sahu

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Abstract

The ability to resolve the issue of solubility of poorly soluble drugs in water is a constant task for the creation of medicines. An example of this is the telmisartan - a popular antihypertensive drug. The present review highlights a thorough assessment of solid dispersion method that can be potentially used to treat telmisartan low solubility in water. The issues presented in the review include an introduction of physicochemical properties of telmisartan and the possible barriers in the dissolution and absorption of drug, alongside a theoretical description and justification of solid dispersion method. Special attention is put on the appearance of carriers, method of preparation and characterization parameters that hold a significant role in determining telmisartan stability and efficiency. The review systematically analyzes the progress of formulation strategies to the solid dispersion method used to enhance telmisartan oral bioavailability showing its pragmatic value and prospects.

Keywords: Telmisartan, Solid Dispersion, Solubility Enhancement, Hydrophilic Polymers, Amorphization Techniques.