Abstract

A REVIEW ON FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES FOR PEPTIC ULCER

Pooja H. V.*, Arpitha B. M., Manyashree S., Mohith H., Pooja V., Chandana K. P.

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Abstract

Peptic ulcer disease is a common gastrointestinal disorder characterized by open sores or lesions in the lining of the stomach or upper part of the small intestine. It is primarily caused by Helicobacter pylori infection, excessive use of nonsteroidal anti-inflammatory drugs (NSAIDs), stress or lifestyle factors. Symptoms typically include burning stomach pain, bloating, nausea and in severe cases, gastrointestinal bleeding. Conventional treatment involves oral administration of anti-ulcer medications, which may be associated with poor patient compliance, gastrointestinal side effects and variable drug bioavailability. Transdermal drug delivery offers a promising alternative for the treatment of peptic ulcers by allowing steady and controlled drug release through the skin, bypassing the gastrointestinal tract. This method enhances bioavailability, reduces dosing frequency and minimizes systemic side effects. The formulation of transdermal patches involves selecting appropriate polymers and plasticizers to ensure drug stability, skin adhesion and consistent release rates. The development of transdermal patches for peptic ulcer therapy represents an innovative and patient-friendly approach. By improving drug delivery and reducing complications associated with oral medications, this system has the potential to enhance therapeutic outcomes and overall patient compliance in the management of peptic ulcer disease.

Keywords: PUD, NSAID‟s, Transdermal Patches.