Abstract

REVIEW ON A PROMISING STRATEGY FOR ENHANCED OCULAR DRUG DELIVERY SYSTEM

Komal A. Baravkar*, Dr. Amita B. Dongare, Prof. Mamta Divekar

Abstract

Nano emulsions are dispersions formed by mixing two immiscible liquids, typically featuring droplet sizes around 100 nanometers. They are known for their clear appearance, enhanced bioavailability, and extended shelf life. These formulations usually include oil, water, surfactants, and cosurfactants, and can be developed using either high-energy or low-energy techniques. In ophthalmology, diluted Nano emulsions are employed to deliver drugs effectively, as they can penetrate deeper into ocular tissues, offer sustained drug release, and minimize both dosing frequency and potential side effects. Various tests such as safety evaluations, stability assessments, pH analysis, and rheological studies are performed to ensure their suitability. Cationic Nano emulsions, which contain positively charged agents, are particularly useful for topical ocular drug delivery, as they enhance drug retention on the eye surface by slowing down clearance, thereby improving absorption. This review highlights the key features of Nano emulsions, especially those used in ophthalmic applications, including their composition, preparation methods, and evaluation criteria.

Keywords: Nano emulsion, ophthalmic formulations /preparation, ocular delivery: barriers.