Abstract

CHALLENGES OF PEDIATRIC PHARMACOTHERAPY: A NARRATIVE REVIEW OF PHARMACOKINETICS, PHARMACODYNAMICS, AND PHARMACOGENETICS

Ankita D. Khade*, Dr. Amita B. Dongare, Prof. Mamta Divekar

Abstract

Pediatrics pharmacotherapy requires tailored approaches due to age-related physiological differences that significantly affect drug pharmacokinetics and pharmacodynamics. The review explores key challenges in pediatric drug therapy, including formulation difficulties, the impact of obesity on dosing. The review also discusses the factors affecting pediatric pharmacotherapy and related diseases. By synthesizing recent findings from the articles published between 2015-2024, this review highlights the importance of advancing pediatric pharmacotherapy collaborative efforts among clinicians, researchers and regulatory bodies to ensure safe and effective treatment outcomes.

Keywords: Obesity, Pediatric pharmacotherapy, Pharmacokinetics, Pharmacodynamics.