Abstract

PHARMACOLOGICAL EVALUATION OF BOSWELLIA SERRATA AGAINST ISONIAZID-RIFAMPIN INDUCED HEPATOTOXICITY IN LABORATORY RATS

Amisha D. Randhir*, Dr. Amita B. Dongare, Ms. Ashlesha S. Gaikwad

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Abstract

In laboratory rats, the hepatoprotective effect of Boswellia serrata, a traditional Ayurvedic remedy, against isoniazidrifampin- induced hepatotoxicity has been assessed. The purpose of the study was to look into how Boswellia serrata extract might prevent liver damage brought on by antitubercular medications. After being split up into groups, the rats were given silymarin, Boswellia serrata extract, and vehicle control. Prevented blood liver enzymes and better histological alterations demonstrated that Boswellia serrata extract greatly prevented liver damage. According to the A research, Boswellia serrata may have hepatoprotective effects because of its antiinflammatory and antioxidant qualities.

Keywords: Boswellia serrata, hepatoprotective activity, Isoniazid-rifampin induced hepatotoxicity, laboratory rats.