Abstract

A REVIEW ON EVALUATION OF 2.5% BENZOYL PEROXIDE AND 5% NIACINAMIDE TOPICAL SERUM IN ACNE MANAGEMENT

Sonali Gadekar*, Nikita Mhaske, Nikita Rathod, Mohammed Sufiyan,

Abstract

vulgaris is among the most common skin disorders, impacting approximately 70–87% of people worldwide. The rising need for efficient and gentle on-skin topical treatments has driven the creation of combination products aimed at various acne-triggering mechanisms. This assessment centres on the creation and testing of a topical serum that includes 2.5% Benzoyl Peroxide (BPO) and 5% Niacinamide. Benzoyl Peroxide is a recognized antimicrobial and keratolytic compound celebrated for its efficacy yet frequently linked to irritation. Niacinamide, a form of vitamin B3, enhances BPO by decreasing inflammation, fortifying the skin barrier, managing oil production, and boosting tolerability. The combined serum provides a well-rounded therapeutic effect by decreasing Propionibacterium acnes growth, lowering inflammation, and stopping the development of new lesions. This review outlines the pharmacological mechanisms, formulation approaches, physicochemical assessments (pH, viscosity, Spreadability, stability), safety aspects, and therapeutic efficacy of the combined serum. The results endorse this dual-action formulation as an effective, stable, and welltolerated choice for treating mild to moderate acne.

Keywords: Acne vulgaris, Benzoyl Peroxide, Niacinamide, Topical serum, Antiinflammatory, Antibacterial, Formulation evaluation.