Abstract

3D PRINTING TECHNOLOGY IN MICRONEEDLE FOR TRANSDERMAL DRUG DELIVERY

Kachare Ishwari Kailas*, Patil Jyoti N., Vanarase Sakshi Dnyaneshwar

Abstract

Transdermal drug delivery helps by pass first-pass metabolism and ensures prolonged, controlled release of medications. However, its efficiency is hindered by the protective barrier of the stratum corneum Microneedles offer a modern transdermal system that is pain-free, minimally invasive, user-friendly, and capable of delivering drugs with enhanced bioavailability.[1] 3D printing is revolutionizing microneedle (MN) fabrication for transdermal drug delivery, offering noninvasive administration, better patient compliance, and bypassing first-pass metabolism. MNs, classified as solid, coated, hollow, and dissolving, enable delivery of drugs, vaccines, and biologics. 3D printing allows precise customization, rapid prototyping, complex designs, and controlled drug release, making MNs suitable for personalized treatments. Despite challenges like slow production, quality issues, and intellectual property concerns, advances in materials, automation, and scalable methods are expected to overcome these barriers. Applications extend to biosensing, cancer therapy, and chronic disease management, positioning 3D-printed MNs as a promising step toward personalized medicine.[2] Microneedles are gaining attention as advanced transdermal drug delivery systems due to improved patient compliance and self-administration compared to traditional injections. However, challenges in precise macroscales fabrication hinder their commercialization, especially for personalized medicine. Recent research highlights the use of 3D printing with various techniques and formulations to create synthetic carriers and bioinspired microneedles. This review outlines these advances, their benefits, limitations, and potential as nextgeneration drug delivery systems.[3]

Keywords: Transdermal delivery, Controlled release, Microneedles, Minimally invasive, Bioavailability, 3D printing, Prototyping, Biosensing.