Abstract

ETHNOPHARMACOLOGY, PHYTOCHEMISTRY, AND PHARMACOLOGICAL EVALUATION OF KHAJURASAVA: AN AYURVEDIC FERMENTED FORMULATION

Dr. Indu Jilowa*, Prof. Rajendra Prasad Sharma, Dr. Reetesh Ramnani, Dr. Asha

Abstract

Rajayakshma, described in Ayurveda as a condition arising from Dhatukshaya and Dhatwagninasana, closely parallels tuberculosis (TB) in modern medicine. Progressive depletion of tissues—rasa, rakta, mamsa, meda, sukra, and ultimately ojas— leads to profound immune compromise (Ojokshaya), forming the core of its pathogenesis. Although Anti-Tubercular Treatment (ATT) remains the mainstay of modern TB therapy, its long-term use is frequently associated with complications such as hepatotoxicity, oxidative stress, inflammation, and reduced patient compliance. These limitations highlight the need for safe, supportive interventions that can enhance therapeutic outcomes. Sandhana Kalpana, an Ayurvedic fermentation process, offers formulations with improved bioavailability and inherent antioxidant, immunomodulatory, and hepatoprotective properties. Khajurasava—prepared from Phoenix dactylifera, Juniperus communis, and Woodfordia fruticosa—is traditionally indicated for Rajayakshma. This review compiles classical references and modern scientific evidence to evaluate the formulation’s potential relevance in TB management. Phytochemical analysis shows that the ingredients are rich in phenolic acids, flavonoids, proanthocyanidins, volatile oils, and tannins. Pharmacological studies demonstrate potent antioxidant, anti-inflammatory, immunomodulatory, hepatoprotective, and lung-protective activities, all of which address key pathological components of TB and its treatment- related toxicities. Collectively, the evidence suggests that Khajurasava may serve as an effective supportive formulation alongside conventional ATT by reducing drug-induced side effects, enhancing immune function, and improving overall treatment tolerance. Future preclinical and clinical studies are warranted to validate its integrative therapeutic role and establish its safety and efficacy in TB management.

Keywords: Rajayakshma, Kharjura, Phytoconstituents, Fermented Formulation.