Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF ACECLOFENAC

Chamundeshwari Wagdale*

Abstract

Aceclofenac is a widely prescribed NSAID for the treatment of osteoarthritis, rheumatoid arthritis, and pain-related inflammatory conditions. Owing to its short elimination halflife of nearly 4 hours, frequent administration is required, which may lead to gastrointestinal irritation and fluctuating plasma drug levels. The present research aims to develop sustained release (SR) matrix tablets of aceclofenac using a combination of hydrophilic polymer Hydroxypropyl Methylcellulose (HPMC K15M) and hydrophobic natural resin rosin oil to achieve controlled drug release. Formulations were prepared by wet granulation using PVP K30 as binder. Precompression parameters such as flow properties were evaluated, followed by post-compression evaluation including hardness, friability, weight variation, thickness, and drug content. In-vitro drug release was performed in pH 7.4 phosphate buffer for 12 hours. FTIR confirmed compatibility between drug and excipients. Results showed that increasing rosin oil concentration reduced the release rate, while HPMC provided matrix swelling and diffusion control. The optimized formulation (F5) containing a balanced ratio of HPMC and rosin oil released 94.2% drug in 12 hours, following zero-order kinetics with non-Fickian diffusion. The study concludes that HPMC combined with rosin oil resin is effective in modulating the sustained release of aceclofenac, offering a cost-effective and stable SR dosage form.

Keywords: sustained release, Rosin oil as Resin, HPMC, Acelcofenac.