Abstract

REVIEW ON: ANTICOAGULATION THERAPY

*Tejas Talan, Dr. Karishma Nikose, Sanjiwani Pawar, Achal Mandale, Siddesh Lande

Abstract

Anticoagulation drugs antagonize coagulation and are used to prevent or cure venous thromboembolism (VTE). Drug to prevent clotting have been used for more then a century. Within this review, we aimed to revise the history of the different anticoagulation that are currently prescribe in the clinic. In addition, we compared their pharmacology properties, medical indication and the difficulties in implementing new anticoagulation in vulnerable patient population. Since the introduction of unfractionated heparin in the 1930s, major advance in the mechanistic understanding and medicinal use of anticoagulation have allowed for significant improvement in treating VTE patient. However, a new generation of anticoagulation is currently being tested in clinical trials, with the goal of further optimizing medical care.

Keywords: venous thromboembolism; anticoagulation drugs; heparin; vitamin K antagonist; DOACs; pharmacology; drug-drug interaction; novel anticoagulation.