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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

CRITICAL REVIEW OF ANIMAL STUDIES ON HOLARRHENA ANTIDYSENTERICA (KUTAJA)

*Dr. Aishwarya Baste, Dr. Pritam Pawale, Dr. Parashuram Pawar, Dr. Vrushali Dani

Abstract

Holarrhena antidysenterica Wall. (Apocynaceae), traditionally known as Kutaja, is a pivotal medicinal plant in Ayurveda, primarily indicated for gastrointestinal disorders such as Atisara (diarrhoea) and Pravahika (dysentery). This article provides a systematic and critical appraisal of published preclinical research, examining the efficacy, experimental models, and pharmacological outcomes of Kutaja in animal subjects. Evidence from various rodent models supports its antidiarrheal, antimalarial, antidiabetic, and wound-healing properties. The alkaloid conessine emerges as a significant bioactive lead.

Keywords: Holarrhena antidysenterica, Kutaja, Animal studies, Conessine, Antidiarrheal, Preclinical, Toxicology.

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