Abstract

COMPARATIVE EFFICACY AND SAFETY OF INTRAMUSCULAR MIDAZOLAM VERSUS INTRAVENOUS LORAZEPAM IN PREHOSPITAL MANAGEMENT OF STATUS EPILEPTICUS: EVIDENCE FROM RAMPART TRIAL

P. Priyadharshini*, S. Lakshmi, V. Anushree, M. Praveenkumar, C. Jothimanivannan

Abstract

Background: Status Epilepticus (SE) is a life-threatening neurological emergency that requires immediate treatment. Intravenous (IV) lorazepam is a standard first-line therapy, but IV access is often delayed in Prehospital settings. Intramuscular (IM) Midazolam offers a potential alternative due to its ease of administration. Objective: To evaluate and compare the effectiveness of IM midazolam and IV lorazepam in terminating seizures in patients with status epilepticus in a Prehospital setting.

Keywords: Status epilepticus (SE), Intramuscular (IM) midazolam, Intravenous (IV) Lorazepam, Emergency Medical Services (EMS), seizure treatment, neurological emergencies.