Abstract

ACECLOFENAC - LOADED NOVEL DRUG DELIVERY SYSTEM FOR ENHANCED ANTI-INFLAMMATORY ACTIVITY

Mr. S. Pragadheeshwaran*, Mr. M. Praveen Kumar, Mr. P. Prakash, Mr. R. Thirumalai, Mr. S. Hari Prasanna, Mr. C. Jothimanivannan

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the treatment of pain and inflammation in musculoskeletal disorders. It belongs to the phenylacetic acid class of NSAIDs and exhibits both analgesic and anti-inflammatory properties. The drug acts mainly by inhibiting cyclooxygenase enzymes, resulting in decreased prostaglandin synthesis. Aceclofenac is widely prescribed in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and low back pain. Several clinical studies have demonstrated its effectiveness in reducing pain and improving joint gastrointestinal tolerability profile. The incidence of adverse effects such as gastric irritation and ulceration is relatively lower. This makes it suitable for longterm use in chronic inflammatory function. Compared to other conventional NSAIDs, aceclofenac shows comparable or superior therapeutic efficacy. An important advantage of aceclofenac is its favorable conditions. Aceclofenac is rapidly absorbed after oral administration and shows good bioavailability. It is extensively metabolized in the liver and excreted mainly through urine. The drug is generally well tolerated when used at recommended doses. However, caution is advised in patients with hepatic, renal, or cardiovascular disorders. Overall, aceclofenac represents an effective and safe NSAID option for managing pain and inflammation.

Keywords: Aceclofenac; Non-steroidal anti-inflammatory drugs (NSAIDs); Analgesic activity; Anti-inflammatory activity; Cyclooxygenase inhibition; Musculoskeletal disorders; Gastrointestinal tolerability; Osteoarthritis; Rheumatoid arthritis; Pharmacokinetics.