Abstract

FORMULATION AND EVALUATION OF NANOGEL FOR ANTIBACTERIAL AND ANTIINFLAMMATORY PROPERTIES OF PERGULARIA DAEMIA

Ms. Tahura J. Shaikh, Mr. Vishal S. Madankar*, Mr. Anil B. Panchal

Abstract

Nanogels have emerged as promising drug delivery systems due to their high biocompatibility, controlled drug release, and enhanced therapeutic efficacy. Pergularia daemia, a medicinal plant widely used in traditional medicine, is known for its significant antibacterial and anti-inflammatory properties attributed to its rich phytochemical composition. The present study focuses on the formulation and evaluation of an herbal nanogel incorporating Pergularia daemia extract to enhance its therapeutic potential. The nanogel was prepared using suitable polymers and cross-linking agents, followed by characterization for physicochemical properties such as particle size, pH, viscosity, spreadability, and stability. The antibacterial activity of the formulated nanogel was evaluated against selected pathogenic microorganisms using standard microbiological methods, while anti-inflammatory activity was assessed through in vitro and/or in vivo models. Results demonstrated that the Pergularia daemia-loaded nanogel exhibited satisfactory physicochemical characteristics, improved stability, and sustained release behaviour. The nanogel showed significant antibacterial activity and notable anti-inflammatory effects compared to the crude extract, indicating enhanced bioavailability and efficacy. Overall, the study suggests that Pergularia daemia-based nanogel formulations hold potential as an effective topical therapeutic system for managing bacterial infections and inflammatory conditions.

Keywords: Nanogel, Pergularia daemia, Antibacterial activity, Anti-inflammatory activity, Phytochemical extract, Topical formulation, Medicinal plant, Controlled drug release.