Abstract

PHYTOCHEMICAL ANALYSIS, THERAPEUTIC APPLICATIONS, TABLETFORMULATION OF MORINGA OLEIFERA FOR DISEASE MANAGEMENT

Prathamesh Shrikhande*, Akash Londhe, Satish Rajale, Neha Tambe, Yash Kapde, Pawan More, Sawale Nitin, Smita Wasnik, Dr. Gajanan Sanap

Abstract

Moringa oleifera Lam., revered as the "miracle tree," has been scientifically validated in this study as a rich source of bioactive compounds with remarkable therapeutic potential. Through advanced GC-MS and HPLC-DAD analyses, we identified quercetin (38.23%), gallic acid (15.62%), and chlorogenic acid (16.76%) as the predominant phytochemicals responsible for its pharmacological effects. The 70% ethanolic extract demonstrated exceptional antioxidant activity (DPPH IC₅₀: 17.5 μg/mL), comparable to ascorbic acid, along with potent antimicrobial action against pathogenic strains like Staphylococcus aureus (MIC: 125 μg/mL) and significant α-glucosidase inhibition (IC₅₀: 0.38 mg/mL), underscoring its antidiabetic properties. Building on these findings, we developed an optimized tablet formulation using gelatin binder that exhibited superior physicochemical characteristics, including optimal hardness (6.3 kg/cm²), low friability (0.31%), and rapid drug release (92.7% in 30 minutes), while maintaining stability under accelerated conditions. This research not only provides a comprehensive phytochemical and pharmacological profile of Moringa oleifera but also delivers a standardized, clinically viable tablet formulation, bridging the gap between traditional medicine and modern therapeutic applications for managing oxidative stress, infections, and metabolic disorders.

Keywords: Moringa oleifera, bioactive compounds, antioxidant, antimicrobial, antidiabetic, tablet formulation.