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World Journal of Pharmaceutical Research (WJPR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
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Abstract

AMLAPITTA AS A PRECURSOR OF METABOLIC SYNDROME: AN INTEGRATIVE REVIEW FROM AYURVEDIC AND BIOMEDICAL PERSPECTIVES

Dr. Ratnesh Kumar Shukla*, Dr. Shraddha Sharma

Abstract

Background: Metabolic Syndrome (MetS) is a rapidly escalating global health crisis involving insulin resistance, central obesity, and dyslipidemia. While modern medicine focuses on managing established metabolic risks, emerging evidence suggests that functional digestive disturbances and low-grade inflammation precede these overt metabolic changes. Objective: This integrative review aims to conceptualize the Ayurvedic diagnosis of Amlapitta not merely as a gastric disorder, but as a prodromal (early warning) stage of Metabolic Syndrome. Discussion: In Ayurveda, Agni (digestive fire) is central to health, and Amlapitta arises from Agni impairment and Pitta aggravation. Classical texts describe a progression from Amlapitta to Medovaha Srotodushti (fat metabolism disorder) and Prameha (diabetes). This parallels biomedical findings where Gastroesophageal Reflux Disease (GERD) is strongly linked to visceral adiposity, cytokine-induced inflammation, and insulin resistance. Both systems indicate that metabolic dysregulation begins in the gut. Conclusion: Identifying Amlapitta as an early metabolic marker offers a novel window for prevention. Integrating Ayurvedic correction of Agni with modern lifestyle interventions at this stage could prevent the progression to full-blown Metabolic Syndrome.

Keywords: Amlapitta, Metabolic syndrome, GERD, Agni; Ama.


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