Abstract

A RESEARCH ON IMPROVISATION IN DISSOLUTION OF OLMESARTAN MEDOXOMIL BY ENHANCING ITS SOLUBILITY USING SOLID DISPERSION TECHNIQUES

Panchal Dhavalkumar M.*, Tiwari Ajaykumar

School of pharmaceutical sciences, Jaipur national university, Jaipur, India.

Abstract

Olmesartan Medoxomil a crystalline substance is a novel drug for the treatment of the hypertension. It is a BCS class II drug, having low aqueous solubility, exhibiting poor dissolution pattern. The purpose of the study was apply the solid dispersion(SD) techniques like kneading method and solvent evaporation method to enhance the solubility and dissolution rate of Olmesartan Medoxomil Solid dispersions were prepared by taking different ratio of drug and polymers by different solid dispersion techniques like kneading method and solvent evaporation method. The prepared solid dispersion were characterised for solubility study and in-vitro dissolution study. It was also characterized by Fourier transformation infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) as well as X-ray powder diffractometry (XRPD). The XRPD spectra of solid dispersion indicated Olmesartan Medoxomil existed in amorphous state, this could be explained the fact that the aqueous solubility of Olmesartan Medoxomil was increased. It was found that saturation solubility, micromeritic properties and dissolution characteristics of solid dispersions were significantly improved than that of pure Olmesartan Medoxomil Hence it could be concluded that solid dispersions could be one of the effective approaches for improved performance of Olmesartan Medoxomil.

Keywords: solid dispersion (SD), Novel Drug Delivery Systems (NDDS),Fourier transformation infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) as well as X-ray powder diffractometry (XRPD).Olmesartan Medoxomil (OLM), Poloxamer- 188 (PXM- 188), Ski