Abstract

FORMULATION AND EVALUATION OF HERBAL ANTIINFLAMMATORY OINTMENT CONTAINING AEGLE MARMELOS LEAF EXTRACT

Mrs. T. Manjula*, Mr. K. Naveen Kumar, Mr. B. Meswanthran, Mr. Dhanush3, Mr. S. Umesh

Abstract

Aegle marmelos L. (bael) is a tree belongs to Rutaceae family, widely grown all over the world. This plant is gaining popularity because of its nutrient-rich fruits and immense traditional medicinal usage and pharmacological properties. Bael is a common plant that originated in India, Bangladesh, Indonesia, China, and other Asian countries, for example, it is a spiritual, religious, and medicinal plant that can be found all over the world. This study evaluate efficacy of an herbal ointment formulated from extracts of Aegle marmelos leaves in case of inflammation. In this research study of formulation and evaluation Herbal ointment of beal leaves due to their anti inflammation property has been Traditionally used for its medicinal properties.The plant material, leaves of Aegle marmelos, was collected, and the leaves were dried in an oven at 50-55ºC for 72 h. The dried leaves were grounded and extracted in each acetone, ethanol and methanol solvents. Extracts were collected and evaporation of solvent was done on rotavapour. Phytochemical analysis showed the presence of carbohydrates, alkaloids, glycoside, flavonoids, saponins, tannins phenols in ethanolic leaf extracts. The plant possesses various significant activities such as antifungal, antioxidant, antibacterial, antiprotozoal, antispermatogenic, anti-inflammatory, anthelmintic, antidiabetic, laxative, febrifuge, and expectorant, chemopreventive, antipyretic, ulcer healing, antigenotoxic, and diuretic. The formulated ointment was evaluated for various physicochemical parameters, including physical appearance (colour, odour, texture), wash ability, pH, spread ability, homogeneity, greasiness, and phase separation. An initial irritancy test was also performed to assess skin compatibility. The results of the evaluation indicated that the formulated herbal ointment exhibited desirable physical properties, was easily washable, had a skin-friendly pH, and demonstrated good spread ability and homogeneity. The irritancy test revealed no immediate adverse reactions on the skin. The fruits are also used to prepare a large number of by products such as candy, panjiri, toffee, jam etc with help of various post harvest technologies which also helps to reduce the post harvest losses and hence increases the shelf life which further helps in value addition and in generation a good income for a needy farmer.

Keywords: Aegle marmelos, Rutaceae, Herbal ointment, Anti inflammation, Phytochemical analysis, Physicochemical parameter.