Abstract

FORMULATION AND EVALUATION OF CURCUMIN CAPSULES FOR ENHANCED CHEMOPREVENTIVE ACTIVITY IN THE EFFECTIVE MANAGEMENT OF PANCREATIC CANCER

G. Ramya, S. Jayashree, R. Kasthuri, S. Dhilipkumar , Dr. P. Sriramcharan*

Abstract

Pancreatic cancer is one of the deadliest cancer in the world, because of its aggressive nature, resistance to traditional treatments, and delayed diagnosis. The use of the chemo preventive agents like curcumin – that inhibits, delays, or reverse carcinogenesis and gained a significant attention as a potential strategy for preventing and controlling pancreatic cancer. Curcuma Longa is a bioactive poly phenolic molecule and having an antioxidant, anti-inflammatory, and antiproliferative properties but its low bioavailability and poor water solubility restrict its therapeutic efficacy. The goal of the current study is to improve the stability, consistency, and patient compliance of curcumin capsules as an oral chemopreventive dosage form. The manufactured curcumin capsules showed quick disintegration within the pharmacopoeial limitations and acceptable physicochemical qualities, according to the results. Drug release teste revealed a prolonged and effective release pattern, increasing curcumin’s potential for bioavailability. The prepared curcumin capsules can serve a as stable and efficient oral chemopreventive dosage form for the treatment and prevention of pancreatic cancer.

Keywords: UV spectrophotometry, curcumin, chemopreventive, pancreatic cancer, capsule formulation, and evaluation.