Abstract

FORMULATION AND EVALUATION OF LIPOSOMAL GEL FROM CENTELLA ASIATICA FOR WOUND HEALING ACTIVITY: A REVIEW

A. Chandra*, M. Chandhru, A. R. Esther Rani, S. Kanish Raj, K. Pugazhendhi, A. Samuel Jasper

Abstract

The present study aims to formulate and evaluate a liposomal gel containing Centella asiatica extract to enhance topical delivery and wound healing activity. Wound healing is a complex biological process involving inflammation, proliferation, and tissue remodeling. Centella asiatica is a wellknown medicinal plant traditionally used for wound healing because of its active constituents such as asiaticoside, madecassoside, and asiatic acid, which promote collagen synthesis and angiogenesis. Liposomes were prepared by various methods like Thin- Flim hydration, Reverse phase Evaporation, Detergent removal, Solvent ( Ether or Ethanol ) Injection, Heating method, Microfluidic devices, and Sonication Method. Characterized for vesicle size, zeta potential, morphology, and entrapment efficiency. The optimized liposomal suspension was incorporated into a suitable gel base to obtain a liposomal gel formulation. The prepared liposomal gel was evaluated for physicochemical parameters such as pH, viscosity, spreadability, drug content, in-vitro drug release, and stability studies. The study concludes that liposomal gel of Centella asiatica is a promising and effective topical delivery system for wound healing applications.

Keywords: Centella asiatica, Liposomes, Liposomal gel, Wound healing, Topical formulation.