Abstract

SYNTHESIS OF NOVEL PYRIMIDINE AND FUSED PYRIMIDINE DERIVATIVES AND THEIR IN VITRO ANTIMICROBIAL AND CYTOTOXIC EVALUATION

Hanan A. Abdel Fattah*, Nermine A. Osman, Amany M. AL-Mahmoudy, Nermine S. EL-Sayed

Abstract

In the present work some novel pyrimidine and fused pyrimidine derivatives were prepared starting from 1-allyl-2-hydrazinyl-4-oxo-6- (3, 4, 5-trimethoxyphenyl)-1, 4-dihydropyrimidine-5-carbonitrile (4) the key intermediate. The structure of new compounds was characterized by IR, 1H, 13CNMR, mass spectral data and elemental analysis. The in vitro antimicrobial activity evaluation for most of new compounds was screened. Most of the tested compounds showed significant antimicrobial activity. Some of the newly synthesized compounds were evaluated for their anticancer activity against breast carcinoma (MCF7) and colon carcinoma (HCT116) cell lines. The anticancer activity showed that compound 4 was the most active one against the two cell lines IC50 (3.87, 4.48μg/ml)

Keywords: pyrimidine, fused pyrimidine derivatives, antimicrobial, cytotoxic activities.