Abstract

PRONIOSOMAL GEL FOR IMPROVED TRANSDERMAL DRUG DELIVERY: AN OVERVIEW

Prashant G. Pandit*, Durgesh R. Parakh, Moreshwar P. Patil

Abstract

Human skin acts as one of the key sites for non-invasive delivery of therapeutic agents into the body and it has verious numerous advantages over oral drug delivery system.but the molecule or compound with high molecular weight(500 Da) can not cross the skin. For that compound reqires some novel techniques, methods to transfer these compound across the skin easily without any side effects. Vesicular system is one of the systems which have potential to transfer high molecular weight compound (hydrophilic as well as lipophilic) across the skin in control manner. But the major drawback of this system is their stability issue, and hence it can not prepare in large quantity both in laboratory scale and in industrial scale, it required some specific condition when formulation is concerned. Proniosomal is advanced concept over niosome and liposome, which have ability to overcome the problem associated with farmal vesicular drug delivery system. Basically, proniosomal gel is a compact semi-solid liquid crystaline (gel) product of non-ionic surfactants easily formed on dissolving the surfactant in minimal amount of acceptable solvent and the least amount of aqueous phase. This compact liquid crystalline gel can be readily converted into niosomes on hydration. This review provides an important overview of preparation, formulation, evaluation and application of proniosome gel as a drug carrier.

Keywords: Vesicuar drug delivery, niosome, liposome, transdermal drug delivery.