Abstract

ROLE OF ACUTE PHASE PROTEIN IN MASTITIS

Dr. Lakshmi R.* and Dr. Jacob Thanislass

Abstract

The acute phase response is a complex systemic early-defence system of reactions activated by trauma, infection, tissue damage, inflammation, stress or neoplasia. One of the most important elements of this response is the increased hepatic synthesis of some plasma proteins, collectively known as acute phase proteins. Acute-phase proteins (APPs) are serum molecules synthesized by many cell categories, especially hepatocytes. Usually, the structure of APPs and acute-phase responses are similar in all species, having universal character in animal kingdom. The concentration of APPs in blood plasma varies in response to infection or inflammation. In recent investigations, it was discovered that some APPs were secreted in bovine milk during clinical mastitis which can be used as a bio marker for early detection of mastitis. The objective of this review is to get an over view about APPs with its role in mastitis.

Keywords: trauma, infection, tissue damage, inflammation, stress or neoplasia.